反应详情

A solution of dicyclohexyl carbodiimide (Aldrich, 3.55 g, 17.23 mmol) in methylene chloride (50 mL) was added dropwise to a slurry comprised of 6-hydroxy-2,5,7,8-tetramethylchroman-2-acetic acid (4.14 g, 15.66 mmol), 4,4'-difluorobenzhydryl piperazine (Schweizerhall, 4.51 g, 15.66 mmol), and 1-hydroxybenzotriazole hydrate (Aldrich, 2.33 g, 17.23 mmol) in methylene chloride (150 mL) which was cooled by an ice/water bath. After the addition was complete, the reaction mixture was allowed to come to ambient temperature and was stirred at ambient temperature for 12 h. The reaction was filtered and the filtrate was concentrated in vacuo. The residue was chromatographed (flash, silica gel, 95:5 methylene chloride/methanol) to give an oil which crystallized from a mixture of ethyl acetate and hexane. The solid was crystallized from ethanol to give 3.67 g (43.8% yield) of the desired product as a white solid.

1. temperaturewas cooled by an ice/water bath
2. additionAfter the addition
3. customto come to ambient temperature
4. filtrationThe reaction was filtered
5. concentrationthe filtrate was concentrated in vacuo
6. customThe residue was chromatographed (flash, silica gel, 95:5 methylene chloride/methanol)
7. customto give an oil which
8. customcrystallized from a mixture of ethyl acetate and hexane
9. customThe solid was crystallized from ethanol