1-Acetoxy-2-bromoethane → 2-Anilino-6-chloro-9-(2-acetoxyethyl)purine

HRID 263940Notes

Reaction equation

HRID 263940 reaction equation
[NH:1]([C:8]1[N:16]=[C:15]2[C:11]([NH:12][CH:13]=[N:14]2)=[C:10]([Cl:17])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:18]([O:21][CH2:22][CH2:23]Br)(=[O:20])[CH3:19]>>[NH:1]([C:8]1[N:16]=[C:15]2[C:11]([N:12]=[CH:13][N:14]2[CH2:23][CH2:22][O:21][C:18](=[O:20])[CH3:19])=[C:10]([Cl:17])[N:9]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 135641-Acetoxy-2-bromoethaneHCID 52718829H-Purin-2-amine, 6-chloro-N-phenyl-

Product 1

HCID 104044762-Anilino-6-chloro-9-(2-acetoxyethyl)purineYield 47%

Procedure

2-Anilino-6-chloropurine was reacted with 2-acetoxyethyl bromide as described above in A.a. 2-Anilino-6-chloro-9-(2-acetoxyethyl)purine was isolated in a 47% yield, mp 193°-194° C.

Sources & evidence

ORD record
ord-05b8077bbc9e4ef0a0b475677bbeff90
Source dataset
uspto-grants-1997_07
Patent number
US05646155

Reaction notes

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