p-Chlorophenacyl bromide → HCID 15269576, compound

HRID 263969Notes

Reaction equation

HRID 263969 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].O=C(C)C[O:15][C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:25]=1[N:24]=[CH:23][CH:22]=[CH:21]2>>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][O:15][C:16]2[CH:17]=[CH:18][CH:19]=[C:20]3[C:25]=2[N:24]=[CH:23][CH:22]=[CH:21]3)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 68303p-Chlorophenacyl bromideHCID 15269575HCID 15269575, compound

Product 1

HCID 15269576HCID 15269576, compoundYield 76%

Procedure

8-(2-(p-Chlorophenyl)-2-oxoethoxy)quinoline (9a) was prepared from 2-bromo-4'-chloroacetophenone by the same procedure as 7a in 76% yield. mp: 111°-112° C.; 1H -NMR (CDCl3): δ5.56 (s, 2H, OCH2), 6.96-8.96 (m, 10 H, Ar--H).

Sources & evidence

ORD record
ord-2389504ec1a14110b937af6d6db752f1
Source dataset
uspto-grants-1997_07
Patent number
US05646164

Reaction notes

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