反应详情

温度

78 °C

To a slurry of 294 g of 5-bromosalicylaldehyde in 3 liters of dry ethanol was added 79.06 g of sodium methoxide and the mixture allowed to stir for 20 minutes. To the resulting yellow slurry was added 410 g of 2-phenyl-4-bromoacetyl-5-methyloxazole and the slurry heated to 78° C. for 2 hours. An additional 250 mg of sodium methoxide was added and heating continued overnight under a nitrogen atmosphere. The reaction was cooled and the solids filtered and washed with ethanol, 393 g, mp 212°-213° C.

1. temperatureheating continued overnight under a nitrogen atmosphere
2. temperatureThe reaction was cooled
3. filtrationthe solids filtered
4. washwashed with ethanol, 393 g, mp 212°-213° C.