HRID263995

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CN(CCOc1ccc(C=C2SC(=O)NC2=O)cc1)c1nc2ccccc2o1

HCID54450184

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1nc2ccccc2o1.CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1nc2ccccc2o1.O

HCID88043875

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

5-(4-[2-(N-Methyl-N-(2-benzoxazolyl)amino)ethoxy]benzylidene)-2,4-thiazolidinedione (1.5 g) in dry 1,4-dioxan (80 ml) was reduced under hydrogen in the presence of 10% palladium on charcoal (2 g) at ambient temperature and atmospheric pressure until hydrogen uptake ceased. The solution was filtered through diatomaceous earth, the filter pad was washed exhaustively with dioxan and the combined filtrates were evaporated to dryness under vacuum. The title compound (mp 147°-9° C.) was obtained after crystallisation from methanol.

WORKUP

后处理

filtrationThe solution was filtered through diatomaceous earth
washthe filter pad was washed exhaustively with dioxan
customthe combined filtrates were evaporated to dryness under vacuum

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d7b30d1548f04ed79cbfa1fd229d4a50
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05646169
来源说明: uspto-grants-1997_07

反应 SMILES

[CH3:1][N:2]([CH2:12][CH2:13][O:14][C:15]1[CH:28]=[CH:27][C:18]([CH:19]=[C:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:17][CH:16]=1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[H][H]>O1CCOCC1.[Pd]>[OH2:4].[CH3:1][N:2]([CH2:12][CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:27][CH:28]=1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[CH3:1][N:2]([CH2:12][CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([CH2:19][CH:20]2[S:24][C:23](=[O:25])[NH:22][C:21]2=[O:26])=[CH:27][CH:28]=1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][CH:9]=[CH:8][C:6]=2[N:7]=1