反应详情

The compounds from (b) above (2.3 g; 0.014 moles) was catalytically hydrogenated using Raney nickel (1 g) in methanolic ammonia (100 mL) under a hydrogen atmosphere at 50 psi. The catalyst was filtered and the solution concentrated in vacuo, leaving a residue that was triturated several times with ethyl ether. The decanted solvent was concentrated to dryness, leaving a pale red solid. Yield: 1.3 g (70%). 1H NMR (CDCl3) δ3.6 (s, 3H), 2.4 (bs, 2H), 2.1 (s, 6H) ppm.

1. filtrationThe catalyst was filtered
2. concentrationthe solution concentrated in vacuo
3. customleaving a residue that
4. customwas triturated several times with ethyl ether
5. concentrationThe decanted solvent was concentrated to dryness
6. customleaving a pale red solid