反应详情

Solid NaOH (6.72 g, 168 mmol) was added to a solution of ethyl (±)-4-(1-dodecenyl)-α-phenyl-1H-pyrazole-1-acetate (44.41 g, 112 mmol) in 500 mL 95% ethanol. The resulting yellow solution was stirred for 1 hour and then concentrated in vacuo. The residue was partitioned between water and ether, the aqueous layer was acidified with concentrated HCl and extracted with ethyl acetate. The ethyl acetate layer was dried over MgSO4, filtered, and concentrated to give a yellow oil (43.4 g) used without further purification.

1. concentrationconcentrated in vacuo
2. customThe residue was partitioned between water and ether
3. extractionextracted with ethyl acetate
4. dry with materialThe ethyl acetate layer was dried over MgSO4
5. filtrationfiltered
6. concentrationconcentrated