Dichloromethane → 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanoic acid hydrochloride

HRID 264280Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 264280
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH2:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[C@H:13]([CH:21]([CH3:23])[CH3:22])[C:14]([O:16]C(C)(C)C)=[O:15])(=[O:11])=[O:10])=[CH:5][CH:4]=1.C(Cl)[Cl:32]>>[ClH:32].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH2:24][C:25]2[CH:26]=[N:27][CH:28]=[CH:29][CH:30]=2)[C@H:13]([CH:21]([CH3:23])[CH3:22])[C:14]([OH:16])=[O:15])(=[O:10])=[O:11])=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 6344DichloromethaneHCID 11797104t-Butyl 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanoate

Produkt 1

HCID 700617032(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanoic acid hydrochloride

Reaktionsbedingungen

Temperatur
-10 °C

Versuchsvorschrift

t-Butyl 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methylbutanoate (5.3 g, 12.2 mmol) is dissolved in methylene chloride (150 mL) and cooled to -10° C. Hydrochloric acid gas is bubbled into the solution for 10 minutes. The reaction mixture is then sealed, warmed to room temperature and stirred for 4 hours. The solvent is then evaporated to provide 2(R)-[[4-methoxybenzenesulfonyl](3-picolyl)amino]-3-methyl-butanoic acid hydrochloride.

Aufarbeitung

  1. customHydrochloric acid gas is bubbled into the solution for 10 minutes
  2. customThe reaction mixture is then sealed
  3. temperaturewarmed to room temperature
  4. customThe solvent is then evaporated

Quellen und Nachweise

ORD-Eintrag
ord-a3aff89067704164b900ff25c9c5c473
Quelldatensatz
uspto-grants-1997_07
Patentnummer
US05646167

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