反应详情

2,3-dihydrobenzofuran (6.0 g, 49.94 mmol) is added over 20 minutes to chlorosulfonic acid (29.09 g, 249.69 mmol) at -20° C. The reaction mixture is quenched by addition of ice followed by water (20 mL). The mixture is then extracted with ethyl acetate. The combined organic extracts are washed with brine, dried (Na2SO4), and the solvent is evaporated. The crude product is purified by silica gel chromatography (30% ethyl acetate/hexane) to give 2,3-dihydrobenzofuran-5-sulfonyl chloride (3.3 g).

1. customThe reaction mixture is quenched by addition of ice
2. extractionThe mixture is then extracted with ethyl acetate
3. washThe combined organic extracts are washed with brine
4. dry with materialdried (Na2SO4)
5. customthe solvent is evaporated
6. customThe crude product is purified by silica gel chromatography (30% ethyl acetate/hexane)