HCID 10647114, compound → 2(R)-[[4methoxybenzenesulfonyl](benzyl)amino]-4-methylpentanoic acid

HRID 264287Notes

Reaction equation

HRID 264287 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([S:9]([N:12]([CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C@H:13]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:14]([O:16]C(C)(C)C)=[O:15])(=[O:11])=[O:10])=[CH:5][CH:4]=1>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([S:9]([N:12]([CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C@H:13]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:14]([OH:16])=[O:15])(=[O:11])=[O:10])=[CH:7][CH:8]=1

Participants

3

Reactant 1

HCID 10647114HCID 10647114, compound

Product 1

HCID 117948032(R)-[[4methoxybenzenesulfonyl](benzyl)amino]-4-methylpentanoic acid

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

t-Butyl 2(R)-[[4-methoxybenzenesulfonyl](benzyl)amino]-4-methylpentanoate (5.38 g, 12.02 mmol) is dissolved in methylene chloride (100.0 mL). Hydrochloric acid gas (from a lecture bottle) is bubbled through the solution for 20 minutes. The reaction is sealed and stirred overnight at room temperature. The solvent is then evaporated to give 2(R)-[[4-methoxybenzenesulfonyl](benzyl)amino]-4-methylpentanoic acid.

Workup

  1. customHydrochloric acid gas (from a lecture bottle) is bubbled through the solution for 20 minutes
  2. customThe reaction is sealed
  3. customThe solvent is then evaporated

Sources & evidence

ORD record
ord-67734e76fe3a4855a4915eea7b5e36de
Source dataset
uspto-grants-1997_07
Patent number
US05646167

Reaction notes

Loading…