Ozone → HCID 19036502, compound

An ozone stream (3 g ozone/hour) was conducted for 50 minutes while stirring through a solution, cooled to -70°, of 11.9 g of (RS)-2-(2-buten-1-yl)-5-chloro-6-methoxy-3,3-dimethyl-1-indanone in 160 ml of anhydrous dichloromethane and 40 ml of anhydrous methanol. Subsequently, the mixture was flushed with oxygen for 5 minutes and with argon for 10 minutes. After the addition of 4.7 ml of dimethyl sulfide, the mixture was stirred at room temperature for 16 hours. The reaction mixture was evaporated in a vacuum, the residue was treated with 120 ml of dichoromethane and, after the addition of 20 ml of water and 20 ml of trifluoroacetic acid, stirred at room temperature for 2 hours. The mixture was subsequently poured into 150 ml of water and neutralized by the spatula-wise addition of sodium hydrogen carbonate while stirring. An additional 50 ml of water were added. The phases were separated and the aqueous phase was extracted twice with 100 ml of dichloromethane each time. The combined organic phases were dried over magnesium sulfate and concentrated in a vacuum. The oil obtained was crystallized from hexane/ethyl acetate. 10.3 g (90%) of (RS)-2-(2-oxoethyl)-5-chloro-6-methoxy-3,3-dimethyl-1-indanone were obtained as a light yellow solid with m.p. 102°-103°.

1. customSubsequently, the mixture was flushed with oxygen for 5 minutes and with argon for 10 minutes
2. additionAfter the addition of 4.7 ml of dimethyl sulfide
3. stirringthe mixture was stirred at room temperature for 16 hours
4. customThe reaction mixture was evaporated in a vacuum
5. additionthe residue was treated with 120 ml of dichoromethane
6. additionafter the addition of 20 ml of water and 20 ml of trifluoroacetic acid
7. stirringstirred at room temperature for 2 hours
8. additionThe mixture was subsequently poured into 150 ml of water
9. additionneutralized by the spatula-wise addition of sodium hydrogen carbonate
10. stirringwhile stirring
11. additionAn additional 50 ml of water were added
12. customThe phases were separated
13. extractionthe aqueous phase was extracted twice with 100 ml of dichloromethane each time
14. dry with materialThe combined organic phases were dried over magnesium sulfate
15. concentrationconcentrated in a vacuum
16. customThe oil obtained
17. customwas crystallized from hexane/ethyl acetate

ORD record

ord-49fd09e5008e44f6b35123cf1e379517

Source dataset

uspto-grants-1997_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05646173