1-Amino-2-propanol → HCID 19036564, compound

Participants

Reaction Steps

A solution of 2.31 g of (RS)-2-(2-oxoethyl)-6-mesyloxy-1-indanone and 110 mg of p-toluenesulfonic acid in 70 ml of anhydrous toluene was heated on a water separator. A solution of 2.58 g of (RS)-1-amino-2-propanol in 20 ml of anhydrous toluene was added dropwise to the boiling solution over a period of 5 minutes. Subsequently, the mixture was boiled for an additional 45 minutes, during which time the solvent was reduced to a volume of 20 ml. The cooled reaction mixture was purified by column chromatography on silica gel (ethyl acetate/hexane 2:3). 0.74 g (28%) of (RS)-1-(7-mesyloxy-1,4-dihydro-indeno[1,2-b]pyrrol-1-yl)-propan-2-ol was obtained as a light brown solid which was used directly in the next reaction.

Provenance & Evidence