反应详情

325 mg of 8-chloro-2-(2-oxoethyl)-1-tetralone and 290 mg of N-acetylethylenediamine were heated to reflux in 14ml of acetic acid under argon for 1 hour. The solvent was removed in a vacuum and the residue was taken up in 10 ml of water and extracted several times with ethyl acetate. Chromatography on 20 g of silica gel with hexane/ethyl acetate 1:1 and then with ethyl acetate gave 190 mg (45%) of N-[2-(9-chloro-4,5-dihydro-1H-benz[g]indol-1-yl)ethyl]-acetamide as yellowish crystals with m.p. 146°-147°.

1. customThe solvent was removed in a vacuum
2. extractionextracted several times with ethyl acetate