N-(2-aminoethyl)acetamide → HCID 19036609, compound

Participants

Reaction Steps

400 mg of 8-methoxy-2-(2-oxoethyl)-1-tetralone were heated to reflux for 15 minutes under argon with 205 mg of N-acetyl-ethylenediamine in 8 ml of toluene. The solvent was removed in a vacuum and the residue was chromatographed on 40 g of silica gel with hexane/ethyl acetate 1:1 and then with ethyl acetate. 280 mg (54%) of N-[2-(4,5-dihydro-9-methoxy-1H-benz[g]indol-1-yl)ethyl]-acetamide were obtained as yellowish crystals with m.p. 132°-133°.

Provenance & Evidence