Trifluoroacetic anhydride → HCID 22851568, compound

Participants

Reaction Steps

5.1 ml (36.8 mmol) of trifluoroacetic anhydride are added to a solution of 6.88 g (24.5 mmol) of (2R,4RS)-1,2-dibenzyl-4-piperidinamine in 20 ml of methylene chloride in an ice-water bath, and stirring is then completed at room temperature for 1 hour. The reaction mixture is evaporated to dryness, resulting in the title compound as pale yellow foam; TLC: methylene chloride/methanol/conc. ammonia (190:9:1), Rf =0.41 (cis) and 0.57 (trans) diastereomer; MS: M+ -91 (benzyl)=285 (14%).

Provenance & Evidence