Sodium borohydride → (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-N-(4-quinolylmethyl)-4-piperidinamine

Participants

Reaction Steps

1.21 g (2.01 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine are reacted with 0.305 mg (8.06 mmol) of sodium borohydride in analogy to Example 2. The title compound ##STR33## is obtained as white foam; TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.37; FD-MS: M+ =503.

Provenance & Evidence