HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 57028147, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 4-Quinolinecarboxaldehyde | HCID 78072 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | (2R*,4S*)-2-Benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 57202094 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 57028147 | HCID 57028147 | — |
Reaction Steps
200 mg (0.468 mmol) of (2R*,4S*)-2-benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine are reacted in analogy to Example 11 with 88 mg (1.4 mmol) of sodium cyanoborohydride, 115 mg (1.4 mmol) of sodium acetate, 134 μl (2.34 mmol) of acetic acid and 294 mg (1.87 mmol) of quinoline-4-carboxaldehyde to give the product. TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.33, FD-MS: M+ =568.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646144 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-280beb62055b419abd069f444096731f |
| Source note | uspto-grants-1997_07 |