HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 57267314, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Diphenylacetic Acid | HCID 8333 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2R*,4S*)-2-Benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 57202094 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 57267314 | HCID 57267314 | — |
Reaction Steps
248 mg (1.17 mmol) of diphenylacetic acid are reacted in analogy to Example 2j first with 128 μl (1.76 mmol) of thionyl chloride and subsequently with 200 mg (0.468 mmol) of (2R*,4S*)-2-benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine to give the product. TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.45, FD-MS: M+ =621.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646144 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-eecddc77f3234ffbb4486d667bc8f5da |
| Source note | uspto-grants-1997_07 |