HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → 1-chloro-10-methyl-9(10H)-acridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | 2-((3-Chlorophenyl)amino)benzoic acid | HCID 83293 | — |
| Reactant | 1-Chloroacridin-9(10H)-one | HCID 12491597 | — |
| Reactant | HCID 20296389 | HCID 20296389 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-chloro-10-methyl-9(10H)-acridinone | HCID 20265003 | — |
Reaction Steps
1-(2-dimethylaminoethoxy)-10-methyl-9(10H)-acridinone [IV; R' is CH3, R" is H, --O--Y--N=Z is 1--O--CH2CH2N(CH3)2 ], hydrochloride salt, m.p. 237°-241° C. (tan granules from methanol-ether). The intermediate 1-chloro-10-methyl-9(10H)-acridinone, m.p. 183°-186° C. (pale yellow granules from ethanol) was prepared by N-methylation of 1-chloro-9(10H)-acridinone, in turn prepared by cyclization of 2-(m-chlorophenylamino)benzoic acid with sulfuric acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04150134 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-58421d0dfa8145088f38952d4daed6e8 |
| Source note | uspto-grants-1979_04 |