Sodium borohydride → (2R*,4S*)-2-Benzyl-1-(3,5-dibromobenzoyl)-N-(4-quinolylmethyl)-4-piperidinamine

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Reaction Steps

0.166 g (0.241 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dibromobenzoyl)-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine is reacted with 0.037 g (0.96 mmol) of sodium borohydride in analogy to Example 2. The title compound ##STR69## is obtained (0.094 g, 66%) as white foam. TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.23, FD-MS: M+ =591,593, 595.

Provenance & Evidence