Phenylacetaldehyde → HCID 57183740, compound

Participants

Reaction Steps

1 g (3.44 mmol) of (2R*,4S*)-2-benzyl-1-t-butyloxycarbonyl-4-piperidinamine is reacted in analogy to Example 11a with 1 ml (4.48 mmol) of phenylacetaldehyde, 0.433 g (6.89 mmol) of sodium cyanoborohydride, 0.791 g (9.64 mmol) of sodium acetate and 434 μl of acetic acid to give the title compound (805 mg, 60%). TLC:methylene chloride/methanol/cone. ammonia (700:50:1) Rf =0.35, FD-MS:M+ =394.

Provenance & Evidence