HRID264732

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=c1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1

HCID6029

Uridine

C9H12N2O6

HCID6328

Methyl iodide

CH3I

HCID61221

Dibutylstannane oxide

C8H18OSn

结构：CCCCO[C@@H]1[C@@H]([C](O)=[SnH2])O[C@@H](n2ccc(=O)[nH]c2=O)[C@@]1(O)CCCC

HCID131720090

未命名化合物

PRODUCTS

生成物

结构：CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1ccc(=O)[nH]c1=O

HCID102212

4-Hydroxy-1-(2-O-methylpentofuranosyl)pyrimidin-2(1H)-one

C10H14N2O6

PROCEDURE

实验过程

As per the procedure of Example 49, uridine (8.5 g) was treated with dibutyl tin oxide (8.2 g, 1 eq). The resulting 2',3'-O-dibutylstannylene uridine was treated with iodomethane (16 ml) at 42° C. as per Example 50 to give a mixture of the 2' and 3' alkylated products (3.5 g) as a foam.

WORKUP

后处理

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