反应详情

4a-Phenyl-1,3-diketo-1,2,3,4,4a,5,6,7-octahydroisoquinoline (3.0 g, 12.45 mmoles) from Ex. 1B was dissolved in 100 ml of glacial acetic acid and 50 ml of dioxane. The catalyst, 5% palladium on carbon (700 mg), was added and the mixture was hydrogenated under 40 psi of hydrogen for 24 hours in a Parr shaker. The catalyst was then filtered off and the filtrate evaporated. The white crystalline 4a-phenyl-1,3-diketo-trans-decahydroisoquinoline was recrystallized from ethanol, mp 180°-182.5°.

1. filtrationThe catalyst was then filtered off
2. customthe filtrate evaporated
3. customThe white crystalline 4a-phenyl-1,3-diketo-trans-decahydroisoquinoline was recrystallized from ethanol, mp 180°-182.5°