Ethanol → ethyl 2,2-bisfluoromethyl-6-nitro-2H-1-benzopyran-4-carboxylate

Participants

Reaction Steps

A mixture of 41.7 of 2,2-bisfluoromethyl-6-nitro-2H-1-benzopyran-4-carboxylic acid, 20 ml of sulfuric acid and 300 ml of ethyl alcohol was heated under refluxing for 6 hours. The reaction mixture was poured into ice-water, and the precipitated crystals were separated by filtration to obtain 42.7 g of ethyl 2,2-bisfluoromethyl-6-nitro-2H-1-benzopyran-4-carboxylate having a melting point of 96°-98° C.

Provenance & Evidence