HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 264826Generated: November 2, 2026
Benzene → N-(2-cyanoethyl)-2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carbothioamide
https://huagongshe.com/reaction/264826
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 2,2-bis(fluoromethyl)-N-(2-cyanoethyl)-6-trifluoromethyl-2H-1-benzopyran-4-carboxamide | HCID 9950752 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-(2-cyanoethyl)-2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carbothioamide | HCID 18424394 | 89.6% |
Reaction Steps
A mixture of 92 mg of N-(2-cyanoethyl)-2,2-bis-fluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carbamide, 60 mg of Lawesson's reagent and 2 ml of benzene was heated while stirring at 80° C. for 1 hour. The reaction mixture was subjected to silica gel chromatography (an eluting solvent: methylene chloride) to obtain 50 mg of N-(2-cyanoethyl)-2,2-bisfluoromethyl-6-trifluoromethyl-2H-1-benzopyran-4-carbothioamide having a melting point of 105°-106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05646310 |
|---|
| Source dataset | uspto-grants-1997_07 |
|---|
| ORD ID | ord-0ed9b22605354171ba86d4ac8fc1e6ea |
|---|
| Source note | uspto-grants-1997_07 |
|---|
