Ethanol → ethyl 2,2-bisfluoromethyl-6-nitro-2H-1-benzopyran-4-carboxylate

Participants

Reaction Steps

A mixture of 41.7 g of 2,2-bis(fluoromethyl)-6-nitro-2H-1-benzopyran-4-carboxylic acid, 20 ml of sulfuric acid and 300 ml of ethyl alcohol was refluxed with heating for 6 hours. The reaction mixture was poured into ice water and crystals separated out were filtered to obtain 42.7 g of 2,2-bis(fluoromethyl)-6-nitro-2H-1-benzopyran-4-carboxylic acid ethyl ester with a melting point of 96°-98° C.

Provenance & Evidence