ethyl 2,2-bisfluoromethyl-6-iodo-2H-1-benzopyran-4-carboxylate → ethyl 6-pentafluoroethyl-2,2-bisfluoromethyl-2H-1-benzopyran-4-carboxylate

HRID 264855Notes

Reaction equation

HRID 264855 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[C:11]2[CH:12]=[C:13](I)[CH:14]=[CH:15][C:10]=2[O:9][C:8]([CH2:19][F:20])([CH2:17][F:18])[CH:7]=1)=[O:5])[CH3:2].[F:21][C:22]([F:30])([F:29])[C:23]([F:28])([F:27])C([O-])=O.[K+]>>[CH2:1]([O:3][C:4]([C:6]1[C:11]2[CH:12]=[C:13]([C:23]([F:28])([F:27])[C:22]([F:30])([F:29])[F:21])[CH:14]=[CH:15][C:10]=2[O:9][C:8]([CH2:19][F:20])([CH2:17][F:18])[CH:7]=1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 19037016ethyl 2,2-bisfluoromethyl-6-iodo-2H-1-benzopyran-4-carboxylateHCID 23667659Propanoic acid, 2,2,3,3,3-pentafluoro-, potassium salt (1:1)

Product 1

HCID 19037090ethyl 6-pentafluoroethyl-2,2-bisfluoromethyl-2H-1-benzopyran-4-carboxylate

Procedure

Using 2,2-bis(fluoromethyl)-6-iodo-2H-1-benzopyran-4-carboxylic acid ethyl ester and potassium pentafluoropropionate, an oily product of 6-pentafluoroethyl-2,2-bis(fluoromethyl)-2H-1-benzopyran-4-carboxylic acid ethyl ester was obtained according to the same method as in Example 23 (4).

Sources & evidence

ORD record
ord-c11f810ea24f40feb70afcc0f7ca210b
Source dataset
uspto-grants-1997_07
Patent number
US05646308

Reaction notes

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