反应详情

2(4-Chlorobutyramido)-4-methyloxazole (2.20 g., 0.018 mol) prepared as described in Example 36 was dissolved with stirring under nitrogen in dry benzene (350 mls.) and 1:5-diazobicyclo[4,3,0]non-5-ene (1.47 g., 0.0118 mol) in dry benzene (50 mls.) was added with stirring over 10 minutes. The mixture was stirred at room temperature, wrapped in foil overnight. The organic layer was washed with water (3 × 100 mls.) dried over magnesium sulphate and evaporated under vacuum. The product was recrystallised from ethyl acetate/hexane. WT.= 0.75 g. m.p. 116° C. (Yield = 41.57%).

1. dissolutionwas dissolved
2. stirringThe mixture was stirred at room temperature
3. customwrapped in foil overnight
4. washThe organic layer was washed with water (3 × 100 mls.)
5. dry with materialdried over magnesium sulphate
6. customevaporated under vacuum
7. customThe product was recrystallised from ethyl acetate/hexane