HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-Hydroxy-4-methoxybenzyl alcohol | HCID 78089 | — |
| Reactant | 1-Bromo-3-methoxypropane | HCID 524551 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 4-Methoxy-3-(3-methoxypropoxy)benzenemethanol | HCID 45108163 | — |
Reaction Steps
7.7 g of 3-hydroxy-4-methoxy-benzyl alcohol, 10.35 g of potassium carbonate and 12.1 g of 1-bromo-3-methoxy-propane are stirred under reflux in 150 ml of acetone for 3 days. After evaporation of the solvent, water is added to the residue and extraction is carried out with ethyl acetate. After evaporation of the solvent the title compound is obtained from the organic extracts by means of FC (240 g of silica gel, dichloromethane/methanol=96:4): Rf (ethyl acetate/hexane=2:1)=0.31.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646143 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-09b73114d8df4a4c995dc3f4e81f87c6 |
| Source note | uspto-grants-1997_07 |