HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylamine → 3-Benzyloxycarbonylamino-2,2-dimethyl-N-methylpropionic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Ethyl 3-(((benzyloxy)carbonyl)amino)-2,2-dimethylpropanoate | HCID 22364460 | — |
| Product | 3-Benzyloxycarbonylamino-2,2-dimethyl-N-methylpropionic acid amide | HCID 22364480 | — |
Reaction Steps
4.19 g of 3-benzyloxycarbonylamino-2,2-dimethylpropionic acid ethyl ester and 50 ml of 33% methylamine (in ethanol) are stirred for 8 days at 60° C. in a bomb tube. The reaction mixture is concentrated by evaporation and the residue is purified by FC (220 g of silica gel, dichloromethane/methanol=95:5). The title compound is obtained: Rf (dichloromethane/methanol=9:1)=0.51.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646143 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-226b4e4afa6149d687063182838c5daf |
| Source note | uspto-grants-1997_07 |