HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-(((Benzyloxy)carbonyl)amino)-2-methylpropanoic acid | HCID 304274 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Product | 3-Benzyloxycarbonylamino-2(r,s)-methylpropionic acid methyl ester | HCID 22364470 | — |
Reaction Steps
22.6 g of 3-benzyloxycarbonylamino-2(R,S)-methylpropionic acid are left to stand for 24 hours in 230 ml of methanol with a few drops of concentrated sulfuric acid. The reaction mixture is concentrated by evaporation and the residue is purified by FC (220 g of silica gel, dichloromethane). The title compound is obtained: Rf (dichloromethane/methanol=95:5)=0.60.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646143 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-ceaa1dcd58ea4feeb5684db6f68b76ff |
| Source note | uspto-grants-1997_07 |