Perchloric Acid → 3-Methylthio-11-phenyl-11H-s-triazolo[3,4-b][3]benzazepine

Participants

Reaction Steps

By a procedure similar to that described in Example 1, 20.0 g of the 4-(2,2-diethoxyethyl)-3-diphenylmethyl-5-methylthio-4H-1,2,4-triazole prepared in Reference Example 16 was added to 50 ml of a 70% aqueous solution of perchloric acid under ice-cooling and the mixture was heated at 60°-65° C. for 20 minutes. The cyclization reaction mixture was further treated as described to obtain 3-methylthio-11-phenyl-11H-s-triazolo[3,4-b][3]benzazepine as crystals. Recrystallization from ethanol yielded colorless platelets melting at 169°-170° C.

Provenance & Evidence