HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium → 1-[(2'-t-Butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxybutyl)-2-propylimidazole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 1-[(2'-t-Butoxycarbonylbiphenyl-4-yl)methyl]-4-butyryl-2-propylimidazole-5-carbonitrile | HCID 19036159 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-[(2'-t-Butoxycarbonylbiphenyl-4-yl)methyl]-4-(1-hydroxybutyl)-2-propylimidazole-5-carbonitrile | HCID 19036310 | 94.3% |
Reaction Steps
Following a procedure similar to that described in Example 45(b), but using 1.13 g of 1-[(2'-t-butoxycarbonylbiphenyl-4-yl)methyl]-4-butyryl-2-propylimidazole-5-carbonitrile [prepared as described in step (a) above] and 0.091 g of sodium borophydride in 23 ml of ethanol, 1.07 g of the title compound were obtained as a viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05646171 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-f94caa5e84494e838b2cc8433466e58d |
| Source note | uspto-grants-1997_07 |