HCID 19036258, compound → HCID 178440081, compound

HRID 265099Notes

Reaction equation

HRID 265099 reaction equation
[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:58][CH2:59][CH3:60])[N:8]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[N:38](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[C:9]=1[C:10]([O:12][CH2:13][O:14][C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])=[O:11])([CH3:4])[CH3:3]>C(O)(=O)C>[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:58][CH2:59][CH3:60])[N:8]([CH2:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:24][CH:23]=2)[C:9]=1[C:10]([O:12][CH2:13][O:14][C:15]([O:17][CH:18]([CH3:19])[CH3:20])=[O:16])=[O:11])([CH3:4])[CH3:3]

Participants

3

Reactant 1

HCID 19036258HCID 19036258, compound

Product 1

HCID 178440081HCID 178440081, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Following a procedure similar to that described in Example 61(b), 0.78 g of isopropoxycarbonyloxymethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in step (a) above] was detritylated by heating it with 75% v/v aqueous acetic acid to give 0.48 g of the title compound as an amorphous solid.

Sources & evidence

ORD record
ord-db2e3ef420404eacaf42055fe75c23e9
Source dataset
uspto-grants-1997_07
Patent number
US05646171

Reaction notes

Loading…