HRID265104

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID19036294

未命名化合物

HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

HCID178440079

未命名化合物

PRODUCTS

生成物

结构：CCCc1nc(C(C)(C)O)c(C(=O)OCC)n1Cc1ccc(-c2ccccc2C(=O)NC(C)(C)C)cc1

HCID19036152

未命名化合物

收率 67.1%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 68(a), but using 4.16 g of ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate (prepared as described in Preparation 9), 6.00 g of N-t-butyl-4'-bromomethylbiphenyl-2-carboxamide (prepared as described in Preparation 38) and 2.14 g of potassium t-butoxide, 5.87 g of the title compound was obtained as crystals, melting at 145°-146° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0ddeccb7908844f2b49bd7054e5f23a0
来源数据集: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05646171
来源说明: uspto-grants-1997_07

反应 SMILES

[OH:1][C:2]([C:5]1[N:6]=[C:7]([CH2:15][CH2:16][CH3:17])[NH:8][C:9]=1[C:10]([O:12][CH2:13][CH3:14])=[O:11])([CH3:4])[CH3:3].[C:18]([NH:22][C:23]([C:25]1[C:26]([C:31]2[CH:36]=[CH:35][C:34]([CH2:37]Br)=[CH:33][CH:32]=2)=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:24])([CH3:21])([CH3:20])[CH3:19].CC(C)([O-])C.[K+]>>[C:18]([NH:22][C:23]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[C:31]1[CH:36]=[CH:35][C:34]([CH2:37][N:8]2[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[C:5]([C:2]([OH:1])([CH3:4])[CH3:3])[N:6]=[C:7]2[CH2:15][CH2:16][CH3:17])=[CH:33][CH:32]=1)=[O:24])([CH3:21])([CH3:20])[CH3:19]