(5-Methyl-2-oxo-1,3-dioxolen-4-yl)methyl 2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate → HCID 178467658, compound

HRID 265134Notes

Reaction equation

HRID 265134 reaction equation
[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[C:38]3[N:42](C(C4C=CC=CC=4)(C4C=CC=CC=4)C4C=CC=CC=4)[N:41]=[N:40][N:39]=3)=[CH:28][CH:27]=2)[C:7]([C:14]([O:16][CH2:17][C:18]2[O:19][C:20](=[O:24])[O:21][C:22]=2[CH3:23])=[O:15])=[C:8]([C:10]([OH:13])([CH3:12])[CH3:11])[N:9]=1)[CH3:2]>C(O)(=O)C>[CH2:1]([O:3][CH2:4][C:5]1[N:6]([CH2:25][C:26]2[CH:31]=[CH:30][C:29]([C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=3[C:38]3[NH:42][N:41]=[N:40][N:39]=3)=[CH:28][CH:27]=2)[C:7]([C:14]([O:16][CH2:17][C:18]2[O:19][C:20](=[O:24])[O:21][C:22]=2[CH3:23])=[O:15])=[C:8]([C:10]([OH:13])([CH3:11])[CH3:12])[N:9]=1)[CH3:2]

Participants

3

Reactant 1

HCID 19036259(5-Methyl-2-oxo-1,3-dioxolen-4-yl)methyl 2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate

Product 1

HCID 178467658HCID 178467658, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Following a procedure similar to that described in Example 82 (b), but detritylating 456 mg of (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl 2-ethoxymethyl-4-(1-hydroxy-1-methylethyl)-1-{4-[2-(trityltetrazol-5-yl)phenyl]phenyl}methylimidazole-5-carboxylate [prepared as described in step (a) above] with a 25% v/v aqueous solution of acetic acid, 286 mg of the title compound were obtained as crystals, melting at 166°-167.5° C.

Sources & evidence

ORD record
ord-b5402b340fac496a96d34d86054c1913
Source dataset
uspto-grants-1997_07
Patent number
US05646171

Reaction notes

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