4-Acetyl-2-butyl-5-cyano-1-tritylimidazole → HCID 178441657, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 1.78 g of 4-acetyl -2-butyl-5-cyano-1-tritylimidazole [prepared as described in step (ii) above] in 80% v/v aqueous acetic acid was stirred at 60° C. for 1 hour. The solution thus obtained was concentrated to dryness by evaporation under reduced pressure. The resulting residue was purified by column chromatography through silica gel, using a 3:1 by volume mixture of hexane and ethyl acetate as the eluent, to give 0.66 g of the title compound as a colorless solid, melting at 77°-78° C.

Provenance & Evidence