HCID 178418443, compound → HCID 178441752, compound

HRID 265175Notes

Reaction equation

HRID 265175 reaction equation
[C:1]([C:4]1[N:5]=[C:6]([CH2:11][CH2:12][CH2:13][CH3:14])[NH:7][C:8]=1[C:9]#[N:10])(=[O:3])[CH3:2].[CH2:15]([Mg]Br)C>>[CH2:11]([C:6]1[NH:7][C:8]([C:9]#[N:10])=[C:4]([C:1](=[O:3])[CH2:2][CH3:15])[N:5]=1)[CH2:12][CH2:13][CH3:14]

Participants

3

Reactant 2

HCID 178418443HCID 178418443, compoundHCID 178441657HCID 178441657, compound

Product 1

HCID 178441752HCID 178441752, compoundYield 51.9%

Procedure

Following a procedure similar to that described in Preparation 24(i), but using ethylmagnesium bromide instead of methylmagnesium bromide, the title compound, melting at 84°-85° C., was obtained in a 51.9% yield.

Sources & evidence

ORD record
ord-89a2fa7364364f11803ffaf0626f7daf
Source dataset
uspto-grants-1997_07
Patent number
US05646171

Reaction notes

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