Chloromethyl isopropyl carbonate → HCID 178440082, compound

HRID 265180Notes

Reaction equation

HRID 265180 reaction equation
OC(C1N=C(CCC)NC=1C(OCOC(=O)C(C)(C)C)=O)(C)C.[OH:24][C:25]([C:28]1[N:29]=[C:30]([CH2:36][CH2:37][CH3:38])[NH:31][C:32]=1[C:33]([OH:35])=[O:34])([CH3:27])[CH3:26].[CH:39]([O:42][C:43]([O:45][CH2:46]Cl)=[O:44])([CH3:41])[CH3:40]>>[OH:24][C:25]([C:28]1[N:29]=[C:30]([CH2:36][CH2:37][CH3:38])[NH:31][C:32]=1[C:33]([O:35][CH2:46][O:45][C:43]([O:42][CH:39]([CH3:41])[CH3:40])=[O:44])=[O:34])([CH3:27])[CH3:26]

Participants

4

Reactant 3

HCID 14787051Chloromethyl isopropyl carbonateHCID 178440080HCID 178440080, compoundHCID 178440085HCID 178440085, compound

Product 1

HCID 178440082HCID 178440082, compoundYield 74.4%

Procedure

Following a procedure similar to that described in Preparation 22(ii), but using 1.06 g of 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid [prepared as described in Preparation 22(i)] and 0.83 g of isopropoxycarbonyloxymethyl chloride, 1.22 g of the title compound, melting at 144°-146° C., were obtained.

Sources & evidence

ORD record
ord-d2d5660662cf4fd88f6f76d26be4b29c
Source dataset
uspto-grants-1997_07
Patent number
US05646171

Reaction notes

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