Phenol → 2-[2-(2-Ethylphenoxy)ethoxy]ethanol

Participants

Reaction Steps

Phenol (13.1 g, 0.28 mol), 15 g (0.33 mol) diethylene glycol monoethyl ether and 31.g (0.31 mol) N,N'-dicyclohexylcarbodiimide are heated for 24 hours at 100°-110° C. After cooling, the mixture is extracted with ether and dried. Evaporation of the reaction mixture and flash chromatography of the residue yields 12.6 g (30%) of phenolic ether.

Provenance & Evidence