Ethyl bromoacetate → HCID 86751055, compound

HRID 265218Notes

Reaction equation

HRID 265218 reaction equation
[C:1]([NH:5][C@H:6]([C:26]([O:28][C:29](=[O:31])[CH3:30])=[O:27])[CH2:7][C:8]1[CH:15]=[C:13]([I:14])[C:12]([O:16][C:17]2[CH:24]=[C:22]([I:23])[C:21]([OH:25])=[C:19]([I:20])[CH:18]=2)=[C:10]([I:11])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[CH2:32]([O:34][C:35](=[O:38])[CH2:36]Br)[CH3:33]>>[C:1]([N:5]([CH2:36][C:35]([O:34][CH2:32][CH3:33])=[O:38])[C@H:6]([C:26]([O:28][C:29](=[O:31])[CH3:30])=[O:27])[CH2:7][C:8]1[CH:15]=[C:13]([I:14])[C:12]([O:16][C:17]2[CH:24]=[C:22]([I:23])[C:21]([OH:25])=[C:19]([I:20])[CH:18]=2)=[C:10]([I:11])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 7748Ethyl bromoacetateHCID 86751056HCID 86751056, compound

Product 1

HCID 86751055HCID 86751055, compound

Procedure

alkylating amino group of t-butyl O-acetyl-thyroxine with bromoacetic acid ethyl ester to give t-butyl O-acetyl-N-carboethoxymethyl-thyroxine; then

Sources & evidence

ORD record
ord-9735ffb623884e96a98d1445e3a998f4
Source dataset
uspto-grants-1997_07
Patent number
US05648272

Reaction notes

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