Sodium Hydroxide → HCID 86751057, compound

HRID 265219Notes

Reaction equation

HRID 265219 reaction equation
[C:1]([N:5]([CH2:32][C:33]([O:35]CC)=[O:34])[C@H:6]([C:26]([O:28]C(=O)C)=[O:27])[CH2:7][C:8]1[CH:15]=[C:13]([I:14])[C:12]([O:16][C:17]2[CH:24]=[C:22]([I:23])[C:21]([OH:25])=[C:19]([I:20])[CH:18]=2)=[C:10]([I:11])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+]>CO>[C:1]([N:5]([CH2:32][C:33]([OH:35])=[O:34])[C@H:6]([C:26]([OH:28])=[O:27])[CH2:7][C:8]1[CH:15]=[C:13]([I:14])[C:12]([O:16][C:17]2[CH:24]=[C:22]([I:23])[C:21]([OH:25])=[C:19]([I:20])[CH:18]=2)=[C:10]([I:11])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86751055HCID 86751055, compound

Product 1

HCID 86751057HCID 86751057, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

hydrolysing the ethyl ester and acetyl groups of t-butyl O-acetyl-N-carboethoxymethyl-thyroxine with sodium hydroxide in methanol and obtaining t-butyl N-carboxymethyl-thyroxine in the same process; and

Sources & evidence

ORD record
ord-33176c8319bd498da2b0d4e7954abf21
Source dataset
uspto-grants-1997_07
Patent number
US05648272

Reaction notes

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