HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Lutidine → (2S, 3S, 5R)-2-(3,4difluorophenyl)-3,5-dimethyl-2-morpholinol hydrobromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| Reactant | 2-Bromo-1-(3,4-difluorophenyl)propan-1-one | HCID 15281274 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (2S, 3S, 5R)-2-(3,4difluorophenyl)-3,5-dimethyl-2-morpholinol hydrobromide | HCID 67706270 | 43.7% |
Reaction Steps
To a solution of 2-bromo-3',4'-difluoropropiophenone (47.3 g, 0.19 mole) in acetronitrile (100 ml) was added a solution of R-2-amino-1-propanol (Aldrich Chemical Co., Milwaukee, Wis. 53233) (15 g, 0.20 mole) and 2,6-lutidine (23.6 g, 0.22 mole) in acetonitrile (50 ml). The reaction was worked up as in Example 1 to give 26.9 g of (2S,3S,5R)-2-(3,4-difluorophenyl)-3,5-dimethyl-2-morpholinol hydrobromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05648347 |
| Source dataset | uspto-grants-1997_07 |
| ORD ID | ord-829105790afa4231aa5f21ec1b0b9324 |
| Source note | uspto-grants-1997_07 |