反应详情

A solution of 2-(methylsulfonylmethyl) acrylic acid (700 mg, 4.26 mmol) in 20 mL of methanol was charged into a Fisher-Porter bottle along with 10% palladium on carbon catalyst under a nitrogen atmosphere. The reaction vessel was sealed and flushed five times with nitrogen and then five times with hydrogen. The pressure was maintained at 50 psig for 16 hours and then the hydrogen was replaced with nitrogen and the solution filtered through a pad of celite to remove the catalyst and the filtrate concentrated in vacuo to give 682 mg 96% of 2-(R,S)-methyl-3-methylsulfonyl propionic acid; formula: ##STR79##

1. customThe reaction vessel was sealed
2. customflushed five times with nitrogen
3. temperatureThe pressure was maintained at 50 psig for 16 hours
4. filtrationthe solution filtered through a pad of celite
5. customto remove the catalyst
6. concentrationthe filtrate concentrated in vacuo