Sodium Methoxide → 8-chloro-3-methoxy-11H-s-triazolo[3,4-b][3]benzazepine

HRID 26528Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][C:10]3=[N:12][N:13]=[C:14](S(C)(=O)=O)[N:9]3[CH:8]=[CH:7][C:6]=2[CH:19]=1.[CH3:20][O-:21].[Na+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:11][C:10]3=[N:12][N:13]=[C:14]([O:21][CH3:20])[N:9]3[CH:8]=[CH:7][C:6]=2[CH:19]=1

Participants

Reactant 2

HCID 10942334Sodium Methoxide

HCID 21323443HCID 21323443, compound

Product 1

HCID 213235188-chloro-3-methoxy-11H-s-triazolo[3,4-b][3]benzazepine

Procedure

The reaction of 8-chloro-3-methylsulfonyl-11H-s-triazolo[3,4-b][3]benzazepine with sodium methoxide yielded 8-chloro-3-methoxy-11H-s-triazolo[3,4-b][3]benzazepine. Colorless needles (as recrystallized from aqueous acetone), melting point: 177°-178° C.

Sources & evidence

ORD record: ord-c21c27a6f7a440e39d73830fe245225c
Source dataset: uspto-grants-1979_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04150139

Reaction notes

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