Sodium Hydroxide → HCID 22916410, compound

Participants

Reaction Steps

1-(7-Ethoxycarbonylheptyl)-2-[4-octyloxyphenyl]-4,5-diphenylimidazole (3.2 g) was reacted with 2N sodium hydroxide in a method similar to Example 9. Column chromatography on silica gel eluted with a dichloro-methane:methanol gradient and recrystallisation from acetonitrile gave 1-(7-carboxyheptyl)-2-[4-octyloxy-phenyl]-4,5-diphenylimidazole (1.7 g, 58.6%) as a white solid, m.p. 114°-115°. Found: C, 78.61; H, 8.23; N, 4.96%; C37H46N2O3 requires: C, 78.41; H, 8.18; N, 4.94%.

Provenance & Evidence