Sodium Hydroxide → HCID 22916353, compound

HRID 265377Notes

Reaction equation

C([O:3][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[C:16]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[N:15]=[C:14]1[S:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])=[O:5])C.[OH-].[Na+]>>[C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:17]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=2)=[C:16]([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:15]=[C:14]1[S:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38])([OH:5])=[O:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 22916402HCID 22916402, compound

Product 1

HCID 22916353HCID 22916353, compound

Procedure

1-(7-Ethoxycarbonylheptyl)-2-octylthio-4,5-diphenylimidazole (1 g) was reacted with 2N sodium hydroxide in a method similar to Example 10 to give, after chromatography on silica gel eluted with a dichloro-methane:methanol gradient, 1-(7-carboxyheptyl)-2 octylthio-4,5-diphenyl-imidazole (0.47 g, 49%) as an oil. Found: C, 73.56; H, 8.59; N, 5.60; S, 6.47%; C31H42N2O2S requires: C, 73.47; H, 8.35; N, 5.53; S, 6.33%.

Workup

customto give
washafter chromatography on silica gel eluted with a dichloro-methane

Sources & evidence

ORD record: ord-8d61908b3c71447b8892bd9d8df1ca60
Source dataset: uspto-grants-1997_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05648373

Reaction notes

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