Ethyl 8-bromooctanoate → HCID 22916350, compound

Participants

Reaction Steps

4,5-Bis(4-methoxyphenyl)imidazole (1.8 g) (J. Med. Chem., 1974, 17, 1182-8) and ethyl 8-bromooctanoate (3.2 g) were reacted in a method similar to Example 9. Column chromatography on silica gel eluted with a dichloro-methane:ethanol gradient gave 1-(7-ethoxycarbonyl-heptyl)-4,5-bis(4-methoxyphenyl)imidazole (2.42 g, 83%) as an oil. Found: C, 72.30; H, 7.72; N, 6.21%; C27H34N2O4 requires: C, 71.97; H, 7.61; N, 6.22%.

Provenance & Evidence