Sodium Hydroxide → HCID 22916332, compound

Participants

Reaction Steps

4,5-Bis(2-chlorophenyl)-1-(7-ethoxycarbonylheptyl)-2-phenylimidazole (1.9 g) was reacted with 2N sodium hydroxide in a method similar to Example 10. The aqueous reaction mixture was evaporated to remove ethanol and acidified to pH 5 with 2N aqueous hydrochloric acid. The resulting white solid was collected and recrystallisation from ethanol gave 1-(7-carboxyheptyl)-4,5-bis(2-chloro-phenyl)-2-phenylimidazole (1.31 g, 73%) as a white solid, m.p. 198°. Found: C, 68.53; H, 5.60; N, 5.37; Cl, 14.79%; C29H28Cl2N2O2 0.2% w/w C2H5OH requires: C, 68.31; H, 5.70; N, 5.40, Cl, 13.69%

Provenance & Evidence