Ethyl 8-bromooctanoate → HCID 22916345, compound

HRID 265388Notes

Reaction equation

HRID 265388 reaction equation
[CH2:1]([C:8]1[NH:9][C:10]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:12]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].Br[CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C:33]([O:35][CH2:36][CH3:37])=[O:34]>>[CH2:36]([O:35][C:33]([CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][N:9]1[C:10]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[C:11]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:12]=[C:8]1[CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7])=[O:34])[CH3:37]

Participants

3

Reactant 2

HCID 264813Ethyl 8-bromooctanoateHCID 22916454HCID 22916454, compound

Product 1

HCID 22916345HCID 22916345, compoundYield 87%

Procedure

2-Heptyl-4,5-diphenylimidazole (1 g) was reacted with ethyl 8-bromooctanoate (1.6 g) in a method similar to Example 9 with a reaction time of 48 hours. Chromatography on silica gel (hexane/ethyl acetate) gave 1-(7-ethoxycarbonyl-heptyl)-2-heptyl-4,5-diphenylimidazole (1.3 g, 87%) as an oil. Found: C, 78.98; H, 9.22; N, 5.76%; C32H44N2O2 requires: C, 78.64; H, 9.08; N, 5.73%;

Sources & evidence

ORD record
ord-506edc9855f2424885e5e23fa421df63
Source dataset
uspto-grants-1997_07
Patent number
US05648373

Reaction notes

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